TMG (Trimethylglycine) for Methylation and Heart Health: Homocysteine Support, Daily Dosing
Overview
TMG is a methyl donor used to support homocysteine metabolism, liver function, and overall methylation status. It shows up in heart health stacks, performance formulas, and longevity routines, especially when people want structured support around B vitamins, protein intake, and recovery.
Some users cover baseline B vitamins via a Multivitamin before adding TMG.
What TMG is and how it works
TMG (trimethylglycine) is glycine with three methyl groups. It can donate a methyl group to homocysteine, helping convert it back to methionine. This supports cardiovascular health, methylation dependent reactions, and osmotic balance in liver cells. It is naturally present in beets and whole grains; supplements provide concentrated powder or capsules.
What you may notice when you try TMG
Homocysteine support
Used to help keep homocysteine in range as part of a plan that includes folate, B12, B6, protein, and lifestyle.
Liver and performance routines
Included in some performance and liver protocols to support methylation capacity during higher protein or creatine use.
Daily energy and clarity
If you were short on methyl donors, improving that environment may show up as slightly steadier energy or focus. Effects are modest.
Training and composition context
Some preworkouts include TMG for potential power and volume support. Any effect depends on full training and recovery.
Safety, dosing and who should skip it
Typical dosing
500 to 2,000 mg per day with meals. Higher only with a clear plan.
Side effects
Possible stomach upset, loose stool, bloating, or slightly stimulated feel at higher doses.
Drug interactions
Use caution if you are on complex cardiac, neurological, or psychiatric meds, or already heavy on methyl donors.
Product quality
Choose third party tested TMG with clear mg per serving and simple excipients.
Who should avoid it
Use caution or get guidance if you
have kidney or significant liver disease
have bipolar or severe mood disorder and notice activation
are pregnant or breastfeeding
develop persistent GI issues, headaches, or feeling overly amped
Final Thoughts
TMG is a targeted tool for methylation and homocysteine support. A sensible setup is 500 to 2,000 mg daily with meals, built on good B vitamin status, protein, and sleep. If labs and notes show benefit without side effects, continue at the lowest helpful dose. If not, simplify the stack.
